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B38503

Bis(2-chloroethyl)amine hydrochloride

Name: Bis(2-chloroethyl)amine hydrochloride
Brand: ALDRICH

98%

Synonym(s):

β,β′-Dichlorodiethylamine hydrochloride, 1,5-Dichloro-3-azapentane hydrochloride, 2,2′-Dichlorodiethylamine hydrochloride, 2-Chloro-N-(2-chloroethyl)ethanamine hydrochloride, Bi(2-chloroethyl)amine hydrochloride, Bis(β-chloroethyl)amine hydrochloride, Bis(2-chloroethyl)ammonium chloride, Di(2-chloroethyl)amine hydrochloride, N,N-Bis(2-chloroethyl)amine hydrochloride, Nornitrogen mustard hydrochloride

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About This Item

Linear Formula:

(ClCH₂CH₂)₂NH·HCl

CAS Number:

821-48-7

Molecular Weight:

178.49

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891737

EC Number:

212-479-5

Beilstein/REAXYS Number:

3550356

MDL number:

MFCD00012515

Assay:

98%

Form:

powder

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Properties

Quality Level

200

assay

98%

form

powder

mp

212-214 °C (lit.)

SMILES string

Cl.ClCCNCCCl

InChI

1S/C4H9Cl2N.ClH/c5-1-3-7-4-2-6;/h7H,1-4H2;1H

InChI key

YMDZDFSUDFLGMX-UHFFFAOYSA-N

Description

General description

Bis(2-chloroethyl)amine hydrochloride is used as a starting material to synthesize piperazine derivatives.

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H290,H302,H314

pcodes

P234 - P260 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

No information available.

flash_point_c

No information available.

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Triazene salts: Design, synthesis, ctDNA interaction, lipophilicity determination, DFT calculation, and antiproliferative activity against human cancer cell lines.

Joanna Cytarska et al.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(3), 303-311 (2019-04-13)

Synthesis, characterization and investigation of antiproliferative activity of nine triazene salts against human cancer cells lines (MV-4-11, MCF-7, JURKAT, HT-29, Hep-G2, HeLa, Du-145 and DAUDI), and normal human mammary epithelial cell line (MCF7-10A) is presented. The structures of novel compounds

Synthesis and cytotoxic activity of a glucuronylated prodrug of nornitrogen mustard.

S Papot et al.

Bioorganic & medicinal chemistry letters, 10(16), 1835-1837 (2000-09-02)

A new glucuronylated prodrug of nornitrogen mustard, incorporating the same spacer group as the doxorubicin prodrug HMR 1826, has been prepared. Upon exposure to E. coli beta-glucuronidase, fast hydrolysis occurs but a lower cytotoxicity against LoVo cancer cells is observed

DNA-binding products of nornitrogen mustard, a metabolite of cyclophosphamide.

K Hemminki

Chemico-biological interactions, 61(1), 75-88 (1987-01-01)

Nornitrogen mustard was shown to bind to the N-7 position of guanine in DNA and guanosine. The initial binding product was NOR-G. N-(2-chloroethyl)-N-[2-(7-guaninyl)ethyl]amine but it was converted with time to a hydroxylated derivative. NOR-OH-G and to a cross-link, G-NOR-G. The

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Global Trade Item Number

SKU	GTIN
B38503-25G	04061833428511
B38503-250G	04061832763811
B38503-100G	04061833428504