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Merck
CN

C66056

4-(4-Chlorophenyl)-4-hydroxypiperidine

99%

Synonym(s):

Haloperidol metabolite I, 4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol

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About This Item

Empirical Formula (Hill Notation):
C11H14ClNO
CAS Number:
39512-49-7
Molecular Weight:
211.69
NACRES:
NA.22
PubChem Substance ID:
24892880
UNSPSC Code:
12352100
EC Number:
254-479-8
MDL number:
MFCD00006001

Key Documents

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Product Name

4-(4-Chlorophenyl)-4-hydroxypiperidine, 99%

InChI key

LZAYOZUFUAMFLD-UHFFFAOYSA-N

InChI

1S/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2

SMILES string

OC1(CCNCC1)c2ccc(Cl)cc2

assay

99%

form

powder

mp

137-140 °C (lit.)

Quality Level

100

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Related Categories

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
10717AJ
26938
17017PS
05020KP
02008PY

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Yasuhiko Higashi et al.
Biomedical chromatography : BMC, 20(9), 964-970 (2006-03-01)
4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). After basic
A B Skorniakova et al.
Sudebno-meditsinskaia ekspertiza, 52(1), 45-48 (2009-04-18)
Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of its metabolites also possess
J Fang et al.
Journal of chromatography. B, Biomedical applications, 682(2), 283-288 (1996-07-12)
An electron-capture gas chromatographic procedure was developed for the analysis of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a metabolite of haloperidol. The assay involved basic extraction of this metabolite from the biological samples, followed by back-extraction with HCl. After basification of the acid phase
Ilse Weuts et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 387-393 (2005-05-17)
The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investigated in
L P Pan et al.
Pharmacogenetics, 8(5), 383-389 (1998-11-24)
In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of reduced haloperidol were assessed by measuring
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