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Merck
CN

D161802

N,N′-Dimethylhydrazine dihydrochloride

98%

Synonym(s):

1,2-Dimethylhydrazine dihydrochloride, N,N′-Dimethylhydrazine (sym.) dihydrochloride

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About This Item

Linear Formula:
CH3NHNHCH3 · 2HCl
CAS Number:
306-37-6
Molecular Weight:
133.02
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24893498
EC Number:
206-183-5
Beilstein/REAXYS Number:
3905684
MDL number:
MFCD00012522

Key Documents

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Product Name

N,N′-Dimethylhydrazine dihydrochloride, 98%

InChI key

WLDRFJDGKMTPPV-UHFFFAOYSA-N

InChI

1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H

SMILES string

Cl[H].Cl[H].CNNC

assay

98%

form

crystals

mp

167-169 °C (dec.) (lit.)

Quality Level

200

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Related Categories

Biochem/physiol Actions

Induces colon cancer in rats and mice.

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC7909
BCBV0675
STBB6282
STBB6073
BCBS6347V

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Hisako Hori et al.
Regulatory toxicology and pharmacology : RTP, 112, 104578-104578 (2020-01-15)
Genotoxicity occurring at the target organs of carcinogenesis is important for understanding the mechanisms of chemical carcinogenicity and also for setting of threshold estimation. In vivo gene mutations have been evaluated by transgenic animal models in which any organ can
Preety Ghanghas et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 239-247 (2016-02-24)
Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents against a variety of cancers owing to their capability in blocking the tumor development by cellular proliferation and by promoting apoptosis. Inflammation is principal cause of colon carcinogenesis. A missing
Vijay L Kumar et al.
Drug development research, 80(8), 1089-1097 (2019-09-01)
Anti-inflammatory drugs are well known to reduce the risk of colon cancer and prophylactic use of such agents is gaining acceptance as a cancer prevention therapy. As artesunate, an antimalarial drug, has been shown to exhibit chemopreventive properties, the present
Reema Narayan et al.
Carbohydrate polymers, 261, 117893-117893 (2021-03-27)
Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm3/g, and particle size of 245.24 ±
Leila Kaeid Sharaf et al.
Nutrition and cancer, 70(6), 946-955 (2018-09-06)
Epidemiological and experimental observations have shown that nonsteroidal anti-inflammatory drugs especially selective cyclooxygenase-2 (COX-2) inhibitors and probiotics reduce the incidence risk of colon cancer. Therefore, the present study was designed to assess the prophylactic potentials of probiotics (Lactobacillus acidophilus and
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Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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