D5431
Diethylamine NONOate diethylammonium salt
≥98%
Synonym(s):
DEA NONOate, DEA/NO diethylammonium salt
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About This Item
Linear Formula:
(CH3CH2)2N–N(N=O)O- (CH3CH2)2NH2+
CAS Number:
Molecular Weight:
206.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Assay:
≥98%
Form:
solid
description
t1/2 16 min phosphate buffer, 22 °C NO release
assay
≥98%
form
solid
shipped in
dry ice
storage temp.
−70°C
SMILES string
CCNCC.CCN(CC)N(O)N=O
InChI
1S/C4H11N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h9H,3-4H2,1-2H3;5H,3-4H2,1-2H3
InChI key
LBJLVZKEUWCGIA-UHFFFAOYSA-N
Application
DEA/NO diethylammonium salt can be used as:
- A nitric oxide (NO) donor.
- A reagent for reductive nitrosylation of Wilkinson′s catalyst.
Used as:
- Reagent for reductive nitrosylation of Wilkinson′s catalyst
- Nitric oxide (NO) donor
Biochem/physiol Actions
NO donor
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
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Articles
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。
Xi Ye et al.
The Journal of physiology, 596(16), 3553-3566 (2018-06-05)
Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca2+ release and subsequent activation of intermediate conductance Ca2+ -activated K+ (IKCa ) channels, which underpins vasodilatation as a result of endothelium-dependent hyperpolarization (EDH) in mouse resistance
Xin Zhang et al.
The Journal of biological chemistry, 277(50), 48472-48478 (2002-10-09)
4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. In the presence of oxygen, NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly fluorescent DAF-2 triazole (DAF-2T). However
Yi Shi et al.
PloS one, 9(9), e107787-e107787 (2014-09-24)
The aging gene p66Shc, is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66Shc deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via protein kinase B.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D5431-50MG | 04061833586235 |