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D7631

5,5-Dimethyl-2,4-oxazolidinedione

Name: 5,5-Dimethyl-2,4-oxazolidinedione
Brand: ALDRICH

Synonym(s):

DMO, Dimethadione, NSC 30152

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About This Item

Empirical Formula (Hill Notation):

C₅H₇NO₃

CAS Number:

695-53-4

Molecular Weight:

129.11

NACRES:

NA.22

PubChem Substance ID:

57654127

UNSPSC Code:

12352100

EC Number:

211-781-4

MDL number:

MFCD00005379

Form:

powder

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Properties

form

powder

Quality Level

200

mp

77-80 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(C)OC(=O)NC1=O

InChI

1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)

InChI key

JYJFNDQBESEHJQ-UHFFFAOYSA-N

Description

Application

Reactant involved in:

Synthesis of nickel benzoannulated or naphthoannulated β-oxatetraazachlorin complex
Being used as a cathepsin K inhibitor

Molecule involved in pharmacological studies including:

Identification of bioequivalent generic substitute for antiepileptic drugs
Screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
Dissolving protein plugs in patients with choledochal cyst / pancreaticobiliary maljunctions

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H351

pcodes

P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Hydrogen ion gradients across the mitochondrial, endosomal and plasma membranes in bloodstream forms of trypanosoma brucei solving the three-compartment problem.

D P Nolan et al.

European journal of biochemistry, 267(15), 4601-4614 (2000-07-21)

Conditions for the use of both [14C]methylamine and 5, 5-dimethyl[14C]oxa-azolidine-2,4-dione (DMO) to measure the H+ concentration of intracellular compartments of monomorphic long thin bloodstream forms of Trypanosoma brucei were established. Neither probe was actively transported or bound to internal components

Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity.

Christian Danielsson et al.

Birth defects research. Part A, Clinical and molecular teratology, 79(8), 595-603 (2007-06-23)

The antiepileptic drugs (AEDs) phenytoin, phenobarbital, dimethadione, and carbamazepine cause a similar pattern of malformations in humans, with an increased risk after polytherapy. The teratogenicity has been linked to cardiac rhythm disturbances and hypoxic damage as a consequence of their

Short-term vision gains at 12 weeks correlate with long-term vision gains at 2 years: results from the BEVORDEX randomised clinical trial of bevacizumab versus dexamethasone implants for diabetic macular oedema.

Hemal Mehta et al.

The British journal of ophthalmology, 102(4), 479-482 (2017-08-06)

To determine whether early vision gains predict long-term visual outcomes in the BEVORDEX randomised clinical trial of bevacizumab or dexamethasone implants for diabetic macular oedema. Post hoc analysis of 68 study eyes (77%) that completed 2 years follow-up of the

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Global Trade Item Number

SKU	GTIN
D7631-5G	04061833427965