D7631
5,5-Dimethyl-2,4-oxazolidinedione
Synonym(s):
DMO, Dimethadione, NSC 30152
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About This Item
Empirical Formula (Hill Notation):
C5H7NO3
CAS Number:
Molecular Weight:
129.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
211-781-4
MDL number:
Form:
powder
InChI key
JYJFNDQBESEHJQ-UHFFFAOYSA-N
InChI
1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)
SMILES string
CC1(C)OC(=O)NC1=O
form
powder
mp
77-80 °C (lit.)
storage temp.
2-8°C
Quality Level
Application
Reactant involved in:
Molecule involved in pharmacological studies including:
- Synthesis of nickel benzoannulated or naphthoannulated β-oxatetraazachlorin complex
- Being used as a cathepsin K inhibitor
Molecule involved in pharmacological studies including:
- Identification of bioequivalent generic substitute for antiepileptic drugs
- Screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Dissolving protein plugs in patients with choledochal cyst / pancreaticobiliary maljunctions
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Sanjeeb Bhandari et al.
Clinical & experimental ophthalmology, 48(4), 462-469 (2019-12-31)
There are limited data on real-world outcomes of cataract surgery in eyes receiving intravitreal treatments for diabetic macular oedema (DMO). Cataract surgery may exacerbate oedema in some eyes with DMO resulting in inferior outcomes. Matched, case-controlled retrospective study of observational
J M Squirrell et al.
Biology of reproduction, 64(6), 1845-1854 (2001-05-23)
In early cleavage stage hamster embryos, the inability to regulate intracellular pH (pHi) properly is associated with reduced developmental competence in vitro. The disruption of mitochondrial organization is also correlated with reduced development in vitro. To determine the relationship between
Catharina Busch et al.
Acta ophthalmologica, 98(7), e801-e806 (2020-03-03)
To investigate clinical baseline characteristics and optical coherence tomography biomarkers predicting visual loss during observation in eyes with diabetic macular oedema (DMO) and good baseline visual acuity (VA). A sub-analysis of a 12-month, retrospective study, including patients with baseline VA
Matias Iglicki et al.
The British journal of ophthalmology, 104(5), 666-671 (2019-08-09)
We aimed to investigate a novel optical coherence tomography (OCT) finding of outer retinal hyperreflective deposits (ORYDs) in patients with naïve diabetic macular oedema (DMO) seen after small gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling. Furthermore
Deirdre L Zander-Fox et al.
Reproductive biomedicine online, 21(2), 219-229 (2010-07-10)
The preimplantation embryo is highly susceptible to in-vitro stress, and although this does not necessarily perturb blastocyst development, it can significantly affect embryo physiology and the ability to form a viable pregnancy. This study determined that the preimplantation mouse embryo
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