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Merck
CN

L040080

Cap A

configured for PerkinElmer, configured for Polygen

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About This Item

NACRES:
NA.21
UNSPSC Code:
12352200

Key Documents

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Product Name

Cap A, configured for PerkinElmer, configured for Polygen

type

for DNA synthesis

product line

Proligo Reagents

form

liquid

storage condition

dry at room temperature

concentration

88.7-108.4 g/L (Acetic Anhydride content, titration)

color

clear

compatibility

configured for PerkinElmer
configured for Polygen

Quality Level

200

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Biochem/physiol Actions

Cap A solution aborts chains bearing unreacted 5′ hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′ hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.

General description

Cap A solution contains acetic anhydride and tetrahydrofuran (THF). It is used after the phosphoramidite reaction/coupling step.

Preparation Note

Acetic Anhydride / Tetrahydrofurane 9.1/90.9 (v/v)

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

Regulatory Information

易制毒化学品（2类）
危险化学品
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Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
HMBK7935
HMBK7794
HMBK7321
HMBK7104
HMBK7071

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