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L060084

Sigma-Aldrich

Oxidizer

MDL number:

Quality Level

type

for DNA synthesis

product line

Proligo Reagents

assay

3.9-4.7 g/L iodine (I) basis (titration)

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Preparation Note

Tetrahyrofurane/Water/Pyridine/Iodine 90.54/9.05/0.41/0.43 (v/v/v/w)

Other Notes

Oxidizer solution, containing tetrahydrofuran (THF), pyridine, iodine and water, is applied to oxidize the chemically unstable trivalent phosphorous triester linkage formed in the coupling reaction to a stable pentavalent phosphate triester. Iodine functions as a mild oxidant and water functions as an oxygen donor.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-2.0 °F - closed cup

Flash Point(C)

-18.9 °C - closed cup

Certificate of Analysis

Certificate of Origin

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