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M10050

3-Methoxybenzamide

Name: 3-Methoxybenzamide
Brand: ALDRICH

97%

Synonym(s):

m-Anisamide

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About This Item

Linear Formula:

CH₃OC₆H₄CONH₂

CAS Number:

5813-86-5

Molecular Weight:

151.16

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24896467

EC Number:

227-379-7

Beilstein/REAXYS Number:

2206857

MDL number:

MFCD00007986

Assay:

97%

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Properties

Quality Level

100

assay

97%

mp

132.5-135.5 °C (lit.)

SMILES string

COc1cccc(c1)C(N)=O

InChI

1S/C8H9NO2/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5H,1H3,(H2,9,10)

InChI key

VKPLPDIMEREJJF-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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ADP-ribosylation of core histones and their acetylated subspecies.

G Golderer et al.

The Biochemical journal, 277 ( Pt 3), 607-610 (1991-08-01)

ADP-ribosylation of core histones was investigated in isolated nuclei of Physarum polycephalum. Core histone species differed in the mode of modification. Whereas ADP-ribosylation of H2A and H2B is sensitive to inhibition by 3-methoxybenzamide, as with most other nuclear acceptor proteins

The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.

Y Ohashi et al.

Journal of bacteriology, 181(4), 1348-1351 (1999-02-11)

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is

Role of ADP-ribosylation in activated monocytes/macrophages.

S Hauschildt et al.

Advances in experimental medicine and biology, 419, 249-252 (1997-01-01)

Stimulating monocytes/macrophages with bacterial lipopolysaccharide (LPS) results in TNF-alpha, IL-1, IL-6 and nitrite (NO2-) formation. Inhibitors of poly(ADP-ribose)polymerase inhibit release of these mediators by preventing mRNA expression indicating that ADP-ribosylation plays a crucial role in the synthesis of these mediators.

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Global Trade Item Number

SKU	GTIN
M10050-5G	04061831817577