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M22601

1-(2-Methoxyphenyl)piperazine

Name: 1-(2-Methoxyphenyl)piperazine
Brand: ALDRICH

98%

Synonym(s):

1-(2-Methoxyphenyl)piperazine, 1-(o-Anisyl)piperazine, 1-(o-Methoxyphenyl)piperazine, N-(2-Methoxyphenyl)piperazine, N-(o-Methoxyphenyl)piperazine, o-Methoxyphenylpiperazine

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆N₂O

CAS Number:

35386-24-4

Molecular Weight:

192.26

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24896714

EC Number:

252-537-7

Beilstein/REAXYS Number:

167888

MDL number:

MFCD00005958

Assay:

98%

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Properties

Quality Level

100

assay

98%

refractive index

n20/D 1.575 (lit.)

bp

130-133 °C/0.1 mmHg (lit.)

mp

35-40 °C (lit.)

density

1.095 g/mL at 25 °C (lit.)

SMILES string

COc1ccccc1N2CCNCC2

InChI

1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3

InChI key

VNZLQLYBRIOLFZ-UHFFFAOYSA-N

Gene Information

mouse ... Htr3a(15561)
rat ... Adra1a(29412), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr7(65032)

Description

Application

1-(2-Methoxyphenyl)piperazine can be used:

To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
To prepare cyclic amine substituted Tröger′s base derivatives.
To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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CuI-catalyzed amination of Troger′s base halides: a convenient method for synthesis of unsymmetrical Troger′s bases

Reddy MB, et al.

Royal Society of Chemistry Advances, 6(100), 98297-98305 (2016)

Synthesis of pyrazolylvinyl ketones from furan derivatives

Sawengngen N, et al.

Organic & Biomolecular Chemistry, 17(19), 4850-4855 (2019)

The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors.

T Ochi et al.

European journal of pharmacology, 409(2), 167-172 (2000-12-06)

The involvement of 5-HT receptors in the antinociceptive effect of FR140423, 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]py razole, was investigated in mice by means of the tail-pinch test. The antinociceptive effect of FR140423 injected i.t. was completely abolished by co-administration of the non-selective serotonin (5-hydroxytryptamine

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Global Trade Item Number

SKU	GTIN
M22601-25G	04061834041702
M22601-5G	04061834041719