M2780
N6-Methyladenosine 5′-monophosphate sodium salt
≥97% (HPLC)
Synonym(s):
6-Me-5′-AMP, N-Methyl-5′-adenylic acid disodium salt
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About This Item
Linear Formula:
C11H15N5O7PNa
CAS Number:
Molecular Weight:
383.23
PubChem Substance ID:
UNSPSC Code:
41106305
NACRES:
NA.22
Assay:
≥97% (HPLC)
Storage temp.:
−20°C
InChI
1S/C11H16N5O7P.2Na/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(23-11)2-22-24(19,20)21;;/h3-5,7-8,11,17-18H,2H2,1H3,(H,12,13,14)(H2,19,20,21);;/q;2*+1/p-2/t5-,7-,8-,11-;;/m1../s1
InChI key
HFOKUKRAZPHTHH-LYYWGVPGSA-L
SMILES string
[Na].CNc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(O)C3O
assay
≥97% (HPLC)
storage temp.
−20°C
Quality Level
Related Categories
Application
N6-Methyladenosine 5′-monophosphate sodium salt can be used in N6-methyladenosine (m6A) ribonucleoprotein immunoprecipitation reactions. m6A has gained a lot of attention in the recent years because the mRNA modification with m6A has been shown to play a role in stability and translational efficiency of mRNA.
Biochem/physiol Actions
A glycogen phosphorylase b activator.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.
Fry N J, et al.
RNA, 23(9), 1444-1455 (2017)
M Morange et al.
European journal of biochemistry, 65(2), 553-563 (1976-06-01)
A series of AMP analogs has been selected in order to better understand the structural requirements (a) for the efficient binding of the activator molecule at the correct site on phosphorylase b from rabbit skeletal muscle and (b) for the
N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Wang X, et al.
Cell, 161(6), 1388-1399 (2015)
Kosuke Taniguchi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 494-512 (2020-01-10)
Intracellular mRNA levels are not always proportional to their respective protein levels, especially in the placenta. This discrepancy may be attributed to various factors including post-transcriptional regulation, such as mRNA methylation (N6-methyladenosine: m6A). Here, we conducted a comprehensive m6A analysis
Leilei Zhou et al.
Genome biology, 20(1), 156-156 (2019-08-08)
Methylation of nucleotides, notably in the forms of 5-methylcytosine (5mC) in DNA and N6-methyladenosine (m6A) in mRNA, carries important information for gene regulation. 5mC has been elucidated to participate in the regulation of fruit ripening, whereas the function of m6A
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