N1280
Norclomipramine hydrochloride
≥98% (TLC), powder
Synonym(s):
N-Desmethylclomipramine
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About This Item
Empirical Formula (Hill Notation):
C18H21ClN2 · HCl
CAS Number:
Molecular Weight:
337.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98% (TLC)
Form:
powder
InChI key
KMDDAZOLOSKTKZ-UHFFFAOYSA-N
SMILES string
Cl.CNCCCN1c2ccccc2CCc3ccc(Cl)cc13
InChI
1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H
assay
≥98% (TLC)
form
powder
color
white to yellow
Quality Level
Related Categories
Biochem/physiol Actions
Tricyclic antidepressant; an active metabolite of clomipramine that preferentially blocks the norepinephrine transporter.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S Härtter et al.
Psychopharmacology, 117(2), 149-153 (1995-01-01)
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in
K Fujita et al.
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
P O Feet et al.
Acta psychiatrica Scandinavica, 89(4), 230-234 (1994-04-01)
A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia. Of 45 patients included (21 dixyrazine, 24 placebo), 16 dropped out
J N King et al.
American journal of veterinary research, 61(1), 80-85 (2000-01-12)
To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages. 9 male and 9 female Beagles. Clomipramine was administered orally at a dose of 1, 2
Clinical pharmacology and therapeutics, 66(2), 152-165 (1999-08-25)
To examine the problems of establishing dose-effect and concentration-effect relationships of antidepressant therapy with clomipramine. This randomized double-blind study compared five fixed doses of clomipramine hydrochloride: 25, 50, 75, 125, and 200 mg/day in hospitalized or day patients at nine
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