N3386
D-(+)-Neopterin
≥97.5% (sum of enantiomers, HPLC)
Synonym(s):
D-erythro-Neopterin
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About This Item
Empirical Formula (Hill Notation):
C9H11N5O4
CAS Number:
Molecular Weight:
253.21
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-924-7
Beilstein/REAXYS Number:
89070
MDL number:
Assay:
≥97.5% (sum of enantiomers, HPLC)
Form:
powder
InChI key
BMQYVXCPAOLZOK-XINAWCOVSA-N
InChI
1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
SMILES string
Nc1nc(O)c2nc(cnc2n1)[C@H](O)[C@H](O)CO
assay
≥97.5% (sum of enantiomers, HPLC)
form
powder
storage temp.
2-8°C
Quality Level
Related Categories
General description
D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.
Application
D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]
Biochem/physiol Actions
Pterin cofactor; precursor of BH4 (tetrahydrobiopterin).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection.
Han F, et al.
Analytical Chemistry, 71(7), 1265-1269 (1999)
Dictyopterin, 6-(d-threo-1,2-dihydroxypropyl)-pterin, a new natural isomer of L-biopterin.
Klein R, et al.
European Journal of Biochemistry, 187(3), 665-669 (1990)
Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells.
Ma S, et al.
Cell Death & Disease, 7(7), e2307-e2307 (2016)
Bohuslav Melichar et al.
Anticancer research, 32(9), 4077-4084 (2012-09-21)
To investigate the relation between intima-media thickness (IMT) and laboratory parameters of atherosclerosis risk in patients with breast carcinoma. IMT and a panel of laboratory parameters associated with the risk of atherosclerosis were studied in 192 patients with histologically-verified breast
N Iu Kon'kova
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (6)(6), 123-126 (2013-02-14)
The study included 71 children with chronic gastroduodenitis aged 5-17 years. PCR DNA was determined by the presence of Helicobacter pylori, human papilloma virus high cancer risk 16, 18 types (HPV), herpes simplex 1 and type 2 (HSV), cytomegalovirus (CMV)
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