O2256
Oxolamine citrate salt
Synonym(s):
5-(2-[Diethylamino]ethyl)-3-phenyl-1,2,4-oxadiazole citrate salt, NSC 100298
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About This Item
Empirical Formula (Hill Notation):
C14H19N3O · C6H8O7
CAS Number:
Molecular Weight:
437.44
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
storage temp.
2-8°C
SMILES string
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCc1nc(no1)-c2ccccc2
InChI
1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key
RBZIGQJSMCOHSS-UHFFFAOYSA-N
Related Categories
Application
Molecule involved in pharmacological studies including:
- Antiinflammatory agents
- Drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Effect on warfarin anticoagulant properties
Signal Word
Warning
Hazard Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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L Kirilmaz et al.
Journal of microencapsulation, 9(2), 167-172 (1992-04-01)
One of the principal uses of microencapsulation for pharmaceuticals has been the preparation of sustained-release dosage forms which have been usually presented in the form of a suspension or gel. However, a non-disintegrating tablet would be a better formulation to
[Therapeutic action of oxolamine in acute tracheo-bronchitis].
G Gunella et al.
La Clinica terapeutica, 100(5), 485-492 (1982-03-15)
Effect of oxolamine on cough sensitivity in COPD patients.
B B Ceyhan et al.
Respiratory medicine, 96(1), 61-63 (2002-02-28)
J McEwen et al.
The Medical journal of Australia, 150(8), 449-450 (1989-04-17)
Twenty reports in Australia, Belgium and The Netherlands have implicated oxolamine-citrate cough-mixtures as a cause of hallucinations in children of less than 10 years of age. Fever is not thought to be a likely alternative explanation. Similar reactions in older
Xuan Zhu et al.
Biopharmaceutics & drug disposition, 28(3), 125-133 (2007-02-14)
The possible reason for the significantly greater AUC of oral warfarin with oral oxolamine in male Sprague-Dawley rats was evaluated. After oral administration of warfarin at a dose of 2 mg/kg to male rats with oxolamine at doses of 10
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