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QBD10314

MAL-dPEG®24-NHS ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C62H111N3O31
Molecular Weight:
1394.55
UNSPSC Code:
12352108
PubChem Substance ID:
329823914
NACRES:
NA.22
MDL number:
MFCD11041160
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assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCN2C(C=CC2=O)=O

InChI

1S/C62H111N3O31/c66-57(5-8-64-58(67)1-2-59(64)68)63-7-10-73-12-14-75-16-18-77-20-22-79-24-26-81-28-30-83-32-34-85-36-38-87-40-42-89-44-46-91-48-50-93-52-54-95-56-55-94-53-51-92-49-47-90-45-43-88-41-39-86-37-35-84-33-31-82-29-27-80-25-23-78-21-19-76-17-15-

InChI key

GRDUWUCYIIEBIS-UHFFFAOYSA-N

Features and Benefits

MAL-dPEG® 24-NHS ester is a heterobifunctional, linear crosslinking reagents containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. N-hydroxysuccinimide (NHS) ester are used widely in reactions with primary amines. The NHS-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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