QBD10503
Azido-dPEG®8-NHS ester
Synonym(s):
2,5-Dioxo-1-pyrrolidinyl 3-[(23-azido-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]propanoate, Polyethylene glycol
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About This Item
Empirical Formula (Hill Notation):
C23H40N4O12
CAS Number:
Molecular Weight:
564.58
UNSPSC Code:
12161502
PubChem Substance ID:
NACRES:
NA.22
MDL number:
assay
>90%
form
solid or viscous liquid
reaction suitability
reaction type: click chemistry, reagent type: cross-linking reagent
reaction type: click chemistry
functional group
NHS ester, azide
polymer architecture
shape: linear
functionality: heterobifunctional
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChI key
AZXJVYAMFTUKFC-UHFFFAOYSA-N
Features and Benefits
The azido-dPEG®8-NHS ester contains an azide function on one end of a single molecular weight dPEG® spacer(32.2 Å) and a reactive group (NHS ester) on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily react with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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