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T54801

2,2,2-Trichloroethanol

ReagentPlus®, ≥99%

Synonym(s):

Trichloroethyl alcohol

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About This Item

Linear Formula:
Cl3CCH2OH
CAS Number:
115-20-8
Molecular Weight:
149.40
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24900284
EC Number:
204-071-0
Beilstein/REAXYS Number:
1697495
MDL number:
MFCD00004677
Assay:
≥99%
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vapor density

5.16 (vs air)

Quality Level

200

vapor pressure

1 mmHg ( 20 °C)

product line

ReagentPlus®

assay

≥99%

refractive index

n20/D 1.49 (lit.)

bp

152-154 °C (lit.)

mp

17.8 °C (lit.)

density

1.56 g/mL at 20 °C (lit.)

SMILES string

OCC(Cl)(Cl)Cl

InChI

1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2

InChI key

KPWDGTGXUYRARH-UHFFFAOYSA-N

Application

The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:
  • Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
  • Preparation of TCE ester of chlorosulfuric acid.
  • Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB5996
SDBB4805
SDBB2904
SDBB1915
SDBB0473

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Preparation of N1?Phenylacetamidine 4?Bromobenzoate Using 2, 2, 2?Trichloroethyl Acetimidate Hydrochloride.
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Organic Syntheses, 174-181 null
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Human mutation, 40(10), 1826-1840 (2019-05-23)
Mutations in genes encoding aminoacyl-tRNA synthetases have been reported in several neurological disorders. KARS is a dual localized lysyl-tRNA synthetase and its cytosolic isoform belongs to the multiple aminoacyl-tRNA synthetase complex (MSC). Biallelic mutations in the KARS gene were described
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Global Trade Item Number

SKUGTIN
T54801-500G04061837025303
T54801-100G04061837025297