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T7650

3,3′,5-Triiodothyroacetic acid

≥90%

Synonym(s):

4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylacetic acid

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About This Item

Empirical Formula (Hill Notation):
C14H9I3O4
CAS Number:
51-24-1
Molecular Weight:
621.93
NACRES:
NA.22
PubChem Substance ID:
57654700
UNSPSC Code:
12352100
EC Number:
200-086-1
MDL number:
MFCD00055931
Assay:
≥90%
Form:
powder
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Quality Segment

200

assay

≥90%

form

powder

storage temp.

−20°C

SMILES string

OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1

InChI

1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)

InChI key

UOWZUVNAGUAEQC-UHFFFAOYSA-N

Gene Information

human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

Application


  • Thyroid hormone research: A study explored the impact of 3,3′,5-Triiodothyroacetic acid on peripheral and neurodevelopmental findings in patients with MCT8 deficiency, highlighting its potential in therapeutic interventions for thyroid-related developmental disorders (Unsal and Hayran, 2024).

  • Neurological disorder management: Research demonstrated the use of 3,3′,5-Triiodothyroacetic acid in addressing impaired T3 uptake and action in cerebral organoids modeling Allan-Herndon-Dudley syndrome, providing insights into its application in managing brain-specific thyroid hormone transport abnormalities (Salas-Lucia et al., 2024).

  • Pharmaceutical development for antiviral therapies: Tiratricol, a derivative of 3,3′,5-Triiodothyroacetic acid, was identified as an inhibitor of yellow fever virus replication by targeting the viral RNA-dependent RNA polymerase, showcasing its potential in antiviral drug development (Ren et al., 2023).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

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