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CN

W222208

Isobutyric acid

≥99%, FCC, FG

Synonym(s):

Isobutanoic acid, 2-Methylpropionic acid

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About This Item

Linear Formula:
(CH3)2CHCO2H
CAS Number:
79-31-2
Molecular Weight:
88.11
FEMA Number:
2222
Council of Europe no.:
6
UNSPSC Code:
12164502
PubChem Substance ID:
24900936
Flavis number:
8.006
EC Number:
201-195-7
NACRES:
NA.21
MDL number:
MFCD00002658
Beilstein/REAXYS Number:
635770
Organoleptic:
butter; acidic; rancid
Grade:
FG
Kosher
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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Product Name

Isobutyric acid, ≥99%, FCC, FG

SMILES string

CC(C)C(O)=O

InChI

1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)

InChI key

KQNPFQTWMSNSAP-UHFFFAOYSA-N

biological source

synthetic

grade

FG
Kosher

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 872/2012
FCC
FDA 21 CFR 172.515

vapor density

3.04 (vs air)

vapor pressure

1.5 mmHg ( 20 °C)

assay

≥99%

autoignition temp.

824 °F

expl. lim.

10 %

refractive index

n20/D 1.393 (lit.)

bp

153-154 °C (lit.)

mp

−47 °C (lit.)

density

0.95 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

butter; acidic; rancid

Quality Level

300
400

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Biochem/physiol Actions

Taste at 15 ppm
Odor at 10 ppm

Application


  • Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody.: This study presents groundbreaking research on how isobutyric acid can enhance the efficacy of anti-PD-1 antibodies, offering significant implications for improving cancer immunotherapy treatments (Murayama et al., 2024).

General description

Isobutyric acid is a volatile fatty acid that can be used as a flavoring agent. It occurs naturally in Ceratonia siliqua L. The gum obtained from the kernels of this species is used as a thickener in the food industry.

Other Notes

Natural occurrence: Roman chamomile, strawberry, dairy products.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

131.0 °F - closed cup

flash_point_c

55 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SHBT4147
SHBT4154
SHBT1679
SHBR1117
SHBQ6445

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Burdock GA
Encyclopedia of Food and Color Additives, 1, 1463-1464 (1997)
Manipulation of colonic bacteria and volatile fatty acid production by dietary high amylose maize (amylomaize) starch granules
Wang X, et al
Journal of Applied Microbiology, 93(3), 390-397 (2002)
Effect of temperature on isobutyric acid loss during roasting of carob kibble
Berna A, et al
Journal of Agricultural and Food Chemistry, 45(10), 4084-4087 (1997)
A Vyalikh et al.
Physical chemistry chemical physics : PCCP, 9(18), 2249-2257 (2007-05-10)
Solid state deuterium NMR has been used to study the molecular motion of d(6)-isobutyric acid (d(6)-iBA) in the pure (unconfined) state and confined in the cylindrical pores of two periodic mesoporous silica materials (MCM-41, pore size 3.3 nm and SBA-15
Ritu Lal et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 911-921 (2009-06-09)
Baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the upper small intestine and rapid clearance from the blood. Arbaclofen placarbil is a novel transported prodrug of
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