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W6578

Pyruvic-1-13C acid

API for Clinical Studies, ≥99 atom % 13C

Synonym(s):

α-Ketopropionic acid-1-13C, 2-Oxopropionic acid-1-13C, 13C Labeled pyruvic acid, Pyruvic acid-1-13C

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About This Item

Linear Formula:
CH3CO13CO2H
CAS Number:
99124-30-8
Molecular Weight:
89.05
NACRES:
NA.12
PubChem Substance ID:
329830758
UNSPSC Code:
12352106
MDL number:
MFCD10566986

Key Documents

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Product Name

Pyruvic-1-13C acid, API for Clinical Studies, ≥99 atom % 13C

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1

SMILES string

CC(=O)[13C](O)=O

InChI key

LCTONWCANYUPML-LBPDFUHNSA-N

grade

cGMP

isotopic purity

≥99 atom % 13C

assay

≥95% (CP)

form

viscous liquid

bp

165 °C

mp

11-12 °C

mass shift

M+1

shipped in

dry ice

storage temp.

-10 to -25°C

Quality Level

400

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Application

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

General description

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

Packaging

Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1C

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

179.6 °F - closed cup

flash_point_c

82 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
MBBD9198
MBBD4793
MBBD7597
MBBD2752
MBBC8639

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Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

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