W6578
丙酮酸-1-13C（游离酸）
API for Clinical Studies, ≥99 atom % 13C
别名:
α-酮丙酸-1-13C, 2-氧丙酸-1-13C, 13C 标记丙酮酸, 丙酮酸-1-13C
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关于此项目
线性分子式:
CH3CO13CO2H
化学文摘社编号:
分子量:
89.05
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
丙酮酸-1-13C（游离酸）, API for Clinical Studies, ≥99 atom % 13C
InChI
1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1
SMILES string
CC(=O)[13C](O)=O
InChI key
LCTONWCANYUPML-LBPDFUHNSA-N
grade
cGMP
isotopic purity
≥99 atom % 13C
assay
≥95% (CP)
form
viscous liquid
bp
165 °C
mp
11-12 °C
mass shift
M+1
shipped in
dry ice
storage temp.
-10 to -25°C
Quality Level
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Application
Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.
General description
Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.
Packaging
Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1C
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
179.6 °F - closed cup
flash_point_c
82 °C - closed cup
Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.
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