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700040P

Avanti

desmosterol-d6

Avanti Research™ - A Croda Brand

Synonym(s):

24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)

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About This Item

Empirical Formula (Hill Notation):
C27H38OD6
CAS Number:
1246298-67-8
Molecular Weight:
390.67
MDL number:
MFCD00010474
NACRES:
NA.25
UNSPSC Code:
12352100
Assay:
>99% (TLC)
Form:
powder
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description

cholesta-5,24-dien-3β-ol-d6

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700040P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

Application

Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

Biochem/physiol Actions

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

Packaging

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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