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700042P

Avanti

4β-hydroxycholesterol-d7

Avanti Research™ - A Croda Brand

Synonym(s):

cholest-5-ene-3b,4b-diol(d7)

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About This Item

Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
1246302-80-6
Molecular Weight:
409.70
MDL number:
MFCD15071187
UNSPSC Code:
12352100
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
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description

cholest-5-ene-3,4-diol-d7

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700042P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@H]1[C@@H](C2=CC[C@H]3[C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)(CC[C@@H]3[C@]2(CC1)C)C)O

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D

InChI key

CZDKQKOAHAICSF-BZNWTYAPSA-N

General description

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Application

4β-hydroxycholesterol-d7 has been used:
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
  • to spike serum samples for mass spectrometry measurements
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

Biochem/physiol Actions

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

Packaging

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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