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700056P

Avanti

lathosterol-d7

Avanti Research™ - A Croda Brand

Synonym(s):

5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)

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About This Item

Empirical Formula (Hill Notation):
C27H39D7O
CAS Number:
2260669-10-9
Molecular Weight:
393.70
MDL number:
MFCD22416731
NACRES:
NA.25
UNSPSC Code:
41141804
Assay:
>99% (TLC)
Form:
powder
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700056P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

Lathosterol is a metabolite of cholesterol present in human breast milk. Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol. Lathosterol-d7 is a deuterated derivative of lathosterol.

Application

Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.

Biochem/physiol Actions

Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis. The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.

Packaging

5 mL Amber Glass Screw Cap Vial (700056P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Flash Point (°F)

No data available

Flash Point (°C)

No data available

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