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700073P

Avanti

T-MAS

Avanti Polar Lipids

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Synonym(s):
14-norlanosterol; 4,4-dimethylzymosterol; T-MAS; 110892, 4,4-dimethylcholest-8(9),24-dien-3β-ol
Empirical Formula (Hill Notation):
C29H48O
CAS Number:
7448-02-4
Molecular Weight:
412.69
NACRES:
NA.25

description

4,4-dimethyl-cholest-8(9),24-dien-3β-ol

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700073P-1mg)

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

storage temp.

−70°C

SMILES string

C[C@]12CCC([C@](CC[C@H](O)C3(C)C)(C)C3CC4)=C4C1CC[C@]2([H])[C@]([H])(C)CCC=C(C)C

InChI

1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1

InChI key

CHGIKSSZNBCNDW-QGBOJXOESA-N

General description

14-demethyl-lanosterol acts as an intermediate in cholesterol biosynthesis. It is used to stimulate oocytes for meiosis. 14-demethyl-lanosterol modulates cumulus expansion.

Application

14-demethyl-lanosterol has been used to reduce cancer cell viability and increase cancer cell sensitivity to erlotinib.

Packaging

5 mL Amber Glass Screw Cap Vial (700073P-1mg)

Storage Class Code

11 - Combustible Solids

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Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management (2009)
The chemistry of the vitamins (1965)
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation
Sukhanova A, et al.
Cancer Discovery, 3(1), 96-111 (2013)

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