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About This Item
Empirical Formula (Hill Notation):
C45H70D6O2
CAS Number:
Molecular Weight:
655.12
MDL number:
NACRES:
NA.12
UNSPSC Code:
12352211
Product Name
desmosterol (D6) ester, Avanti Research™ - A Croda Brand
description
26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate)
assay
>99% (TLC)
form
methylene chloride solution
packaging
pkg of 1 × 1 mL (700184M-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
1 mg/mL (700184M-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
Biochem/physiol Actions
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
Packaging
5 mL Clear Glass Sealed Ampule (700184M-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
wgk
WGK 2
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