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About This Item
Empirical Formula (Hill Notation):
C18H33NaO3
CAS Number:
Molecular Weight:
320.44
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
2-OHOA, 2-hydroxyoleic acid (sodium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (791056P-1g)
manufacturer/tradename
Avanti Research™ - A Croda Brand 791056P
lipid type
neutral lipids
neutral glycerides
shipped in
dry ice
storage temp.
−20°C
General description
2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.
Application
2-hydroxyoleic acid (2-OHOA) is suitable for use:
- to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
- to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
- as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)
Biochem/physiol Actions
2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
Packaging
20 mL Clear Glass Screw Cap Vial (791056P-1g)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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