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About This Item
Empirical Formula (Hill Notation):
C50H94GdN5O8
CAS Number:
Molecular Weight:
1050.56
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
DTPA-BSA (Gd), DTPA-bis(stearylamide) (gadolinium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 mg (791268P-100mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 791268P
shipped in
dry ice
storage temp.
−20°C
General description
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) is an amphiphilic molecule with paramagnetic property.
Application
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) has been used:
- in the preparation of nontargeting (NT) gadolinium peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) of atherosclerotic lesions
- as a MRI agent in the preparation of lipid-like nanoparticles (LLNs) for small interfering RNA (siRNA) encapsulation
- as a MRI agent in the preparation of paramagnetic saposin C and dioleylphosphatidylserine (SapC-DOPS) vesicles for imaging glioblastoma multiforme (GBM) tumors
Biochem/physiol Actions
Gd-DTPA-BSA is useful as magnetic resonance imaging (MRI) agent and the gadolinium ion enables the generation of bright images by lowering the longitudinal relaxation time.
Packaging
5 mL Amber Glass Screw Cap Vial (791268P-100mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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F Jasanada et al.
Bioconjugate chemistry, 7(1), 72-81 (1996-01-01)
In order to use the LDL receptor pathway to target radionuclides to cancer sites for imaging and diagnostic purposes, a labeling procedure of LDL with 111In using the DTPA-bis(stearylamide) (L) has been developed. This bifunctional ligand is intended to be
Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
Luo X, et al.
Nanoscale, 9(4), 1575-1579 (2017)
Sang Pil Yoo et al.
ACS omega, 1(5), 996-1003 (2016-12-06)
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 791268P-100MG | 04061835189663 |