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791637C

Avanti

15:0-18:1-d7-PC

Avanti Polar Lipids

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Synonym(s):
1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C41H73 D7 NO8 P
CAS Number:
2097561-16-3
Molecular Weight:
753.09
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (791637C-1mg)

manufacturer/tradename

Avanti Polar Lipids

concentration

1 mg/mL (791637C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

15:0-18:1-d7-PC (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine) is a deuterated phospholipid. The lipid comprises phosphatidylcholine attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phospholipids, in general are amphiphilic and have phosphocholine moiety attached to sn-3 position of glycerol. Phosphatidylcholine is a glycerophospholipid and is a cell membrane component.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH® LIPIDOMIX® Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.

Application

15:0-18:1-d7-PC (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine) has been used:
  • as a component of extraction solvent for lipid isolation from biological samples
  • as an internal standard for spiking serum samples for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • as an internal standard in analysis of lipids from cystic fibrosis derived cell lines

Biochem/physiol Actions

Phosphatidylcholine (PC) levels are crucial for mediating various cellular processes including membrane movement and cell differentiation. A disturbance in PC levels is implicated in various metabolic disorders.

Packaging

2 mL Amber Glass Sealed Ampule (791637C-1mg)

Legal Information

LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.

also commonly purchased with this product

Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

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V Craige Trenerry et al.
Food chemistry, 141(2), 1451-1460 (2013-06-26)
Milk polar lipids are an important class of biologically active species for human health and for improving the physical functionality of food ingredients. Milk polar lipids from 144 multiparous Holstein-Friesian dairy cows fed different diets were analysed using ultra-high-performance liquid
Bjoern Titz et al.
Computational and structural biotechnology journal, 18, 1056-1073 (2020-05-19)
Cigarette smoke (CS) causes adverse health effects and, for smoker who do not quit, modified risk tobacco products (MRTPs) can be an alternative to reduce the risk of developing smoking-related diseases. Standard toxicological endpoints can lack sensitivity, with systems toxicology
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
Alessandra Mingione et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 110-125 (2020-01-31)
Cystic Fibrosis (CF) is an inherited disease associated with a variety of mutations affecting the CFTR gene. A deletion of phenylalanine 508 (F508) affects more than 70% of patients and results in unfolded proteins accumulation, originating a proteinopathy responsible for
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using
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