Product Name
18:0 PEG2000 PE CF, Avanti Research™ - A Croda Brand 810120C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810120C-1mg)
pkg of 1 × 1 mL (810120C-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810120C
concentration
0.5 mg/mL (810120C-500ug)
1 mg/mL (810120C-1mg)
shipped in
dry ice
storage temp.
−20°C
Application
18:0 PEG2000 PE CF may be used:
- in in vitro release assays from nanoemulsion (NE)
- for the labeling PEGylated LPD (liposome-polycation-DNA) for size exclusion chromatography studies
- as a fluorescent probe to monitor shape transformation in giant vesicles
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) conjugate is useful in designing biointerfaces. Lipid-anchored poly(ethylene glycol) (PEG) polymers aid in liposomal drug delivery. PEG-PE liposomes aid in the controlled release of drugs and are promising drug carriers. 18:0 PEG2000 PE CF, also called the DSPE−PEG2000, is a stable polymeric micelle, which favors hydrophobic drug circulation by preventing uptake by mononuclear phagocyte system. DSPE−PEG2000 is a potential drug carrier for cancer therapy.
General description
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) lipid comprises hydrophilic polyethylene glycol (PEG) polymer in its head groups.
Packaging
5 mL Clear Glass Sealed Ampule (810120C-1mg)
5 mL Clear Glass Sealed Ampule (810120C-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
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PEG-Lipid Post Insertion into Drug Delivery Liposomes Quantified at the Single Liposome Level
Eliasen R, et al.
Advanced Materials Interfaces, 6(9), 1801807-1801807 (2019)
Molecular-matched materials for anticancer drug delivery and imaging
Wang D, et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(19), 3003-3013 (2015)
Repeated injections of PEG-PE liposomes generate anti-PEG antibodies
Sroda K, et al.
Cellular & Molecular Biology Letters, 10, 37-47 (2005)
Nanoparticles evading the reticuloendothelial system: role of the supported bilayer
Li SD and Huang L
Biochimica et Biophysica Acta - Biomembranes, 1788(10), 2259-2266 (2009)
Morphology and physical properties of hydrophilic-polymer-modified lipids in supported lipid bilayers
Kakimoto Y, et al.
Langmuir, 34(24), 7201-7209 (2018)
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