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关于此项目
经验公式（希尔记法）:
C24H39N5O5
化学文摘社编号:
分子量:
477.60
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
NBD Sphingosine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810205X-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810205X
concentration
0.25 mg/mL (810205X-250ug)
shipped in
dry ice
storage temp.
−20°C
General description
Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.
Application
NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:
- as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
- to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
- to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16
Biochem/physiol Actions
Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.
Packaging
5 mL Amber Glass Screw Cap Vial (810205X-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
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Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
>125.5 °F
flash_point_c
> 51.95 °C