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关于此项目
经验公式（希尔记法）:
C24H39N5O5
化学文摘社编号:
分子量:
477.60
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
NBD Sphingosine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810205X-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810205X
concentration
0.25 mg/mL (810205X-250ug)
shipped in
dry ice
storage temp.
−20°C
Application
NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:
- as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
- to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
- to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16
Biochem/physiol Actions
Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.
General description
Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.
Packaging
5 mL Amber Glass Screw Cap Vial (810205X-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
>125.5 °F
flash_point_c
> 51.95 °C
法规信息
新产品
此项目有
Sphingosine increases the permeability of model and cell membranes
Contreras FX, et al.
Biophysical Journal, 90(11), 4085-4092 (2006)
F-Xabier Contreras et al.
Biophysical journal, 90(11), 4085-4092 (2006-03-15)
Sphingosine, at 5-15 mol % total lipids, remarkably increases the permeability to aqueous solutes of liposomal and erythrocyte ghost membranes. The increased permeability cannot be interpreted in terms of leakage occurring at the early stages of a putative membrane solubilization
Dan-Dan Song et al.
Cell death & disease, 8(7), e2912-e2912 (2017-07-07)
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons
Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.
Kamilah Castro et al.
EBioMedicine, 43, 392-410 (2019-04-15)
Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS. Fifty-four therapy-naive Relapsing Remitting
Eun A Ra et al.
Nature communications, 7, 11726-11726 (2016-05-25)
Autophagy is responsible for the bulk degradation of cytosolic constituents and plays an essential role in the intestinal epithelium by controlling beneficial host-bacterial relationships. Atg5 and Atg7 are thought to be critical for autophagy. However, Atg5- or Atg7-deficient cells still
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