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810209P

Avanti

C6-NBD Ceramide

Avanti Research™ - A Croda Brand

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C30H49N5O6
CAS Number:
94885-02-6
Molecular Weight:
575.74
MDL number:
MFCD02259244
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810209P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO

InChI

1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1

InChI key

HZIRBXILQRLFIK-VPZZKNKNSA-N

General description

C6-NBD ceramide is a fluorescent labelled compound, known to be useful for the detection of enzymatic action. C6-NBD ceramide is preferred over radioactive compounds.

Application

C6-NBD Ceramide is suitable as a substrate for sphingomyelin synthase activity assay.

Biochem/physiol Actions

Ceramide is one of the products of sphingolipid metabolism. The members of ceramide synthases family are responsible for its synthesis. Each ceramide synthesized differs in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

Packaging

5 mL Amber Glass Screw Cap Vial (810209P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

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Certificates of Analysis (COA)

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Articles

Fluorescent Lipid Probes - Avanti Research™

Explore full-spectrum fluorophores, fluorescent lipids, and probes for imaging, membrane studies, and labeling with TopFluor™, squaraines, and more.

Handbook of Glycosyltransferases and Related Genes, 5-5 (2011)
A role for ceramides, but not sphingomyelins, as antagonists of insulin signaling and mitochondrial metabolism in C2C12 myotubes
Park M, et al.
The Journal of Biological Chemistry, 291(46), 23978-23988 (2016)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)

Global Trade Item Number

SKUGTIN
810209P-1MG04061835190232