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Merck
CN

840009P

Avanti

PAF (from Heart PC)

Avanti Research™ - A Croda Brand

Synonym(s):

1-alkyl-2-acetoyl-sn-glycero-3-phosphocholine

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About This Item

CAS Number:
65154-06-5
MDL number:
MFCD00043214
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

PAF (from Heart PC), Avanti Research™ - A Croda Brand 840009P, powder

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840009P-10mg)
pkg of 1 × 25 mg (840009P-25mg)
pkg of 1 × 5 mg (840009P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840009P

lipid type

phospholipids
phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O

InChI

1S/C12H26NO7P/c1-6-17-9-12(20-11(2)14)10-19-21(15,16)18-8-7-13(3,4)5/h12H,6-10H2,1-5H3/t12-/m1/s1

InChI key

OLGKYSVSAKLUHK-GFCCVEGCSA-N

General description

Platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), an endogenous phospholipid is synthesized by several cells. PAF is a phosphatidylcholine derivative.

Biochem/physiol Actions

Platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is linked with arterial thrombosis, endotoxic shock, acute inflammation and acute allergic disease. It acts as a mediator of pathogenesis of ulcerative colitis and Crohn′s disease in human colon. It also participates in platelet activation and inflammation.

Packaging

5 mL Clear Glass Sealed Ampule (840009P-10mg)
5 mL Clear Glass Sealed Ampule (840009P-25mg)
5 mL Clear Glass Sealed Ampule (840009P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

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PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function
Bechler ME and Brown WJ
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831(3), 595-601 (2013)
Thromboxane A2-mediated Cl- secretion induced by platelet-activating factor in isolated rat colon
Suzuki T, et al.
European Journal of Pharmacology, 400(2-3), 297-303 (2000)

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