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840037P

Avanti

16:0 PS

Avanti Polar Lipids

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Synonym(s):
1,2-dihexadecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DPPS; PS(16:0/16:0); 110668
Empirical Formula (Hill Notation):
C38H73NO10PNa
CAS Number:
145849-32-7
Molecular Weight:
757.95
NACRES:
NA.25

description

1,2-dipalmitoyl-sn-glycero-3-phospho-L-serine (sodium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840037P-10mg)
pkg of 1 × 200 mg (840037P-200mg)
pkg of 1 × 25 mg (840037P-25mg)
pkg of 1 × 500 mg (840037P-500mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C38H74NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-36(40)46-31-34(32-47-50(44,45)48-33-35(39)38(42)43)49-37(41)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h34-35H,3-33,39H2,1-2H3,(H,42,43)(H,44,45);/q;+1/p-1/t34-,35+;/m1./s1

InChI key

GTLXLANTBWYXGW-CEGNZRHUSA-M

General description

Phosphatidylserine (PtdSer) is an anionic phospholipid abundantly present in the eukaryotic cell. 10% of the total cellular lipid consists of phosphatidylserine. O‐phospho‐L‐serine is a heat‐stable substrate.

Application

16:0 PS has been used in the assay to measure interactions between purified dynamin-related protein 1 (Drp1) and synthetic liposomes.
16:0 PS may be used in liposome flotation assay to measure its interactions between purified dynamin related protein 1 (Drp1) and as a component in the lipid mixtures to prepare lipid monolayers. It has also been used to prepare liposomes by the lipid film hydration method.

Biochem/physiol Actions

Phosphatidylserine (PtdSer) participates in various intracellular signaling pathways. It also play a major role in apoptosis and blood clotting.

Packaging

20 mL Clear Glass Screw Cap Vial (840037P-200mg)
30 mL Amber Wide Mouth Bottle with Screw Cap (840037P-500mg)
5 mL Amber Glass Screw Cap Vial (840037P-10mg)
5 mL Amber Glass Screw Cap Vial (840037P-25mg)

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

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Condensation of Model Lipid Films by Cholesterol: Specific Ion Effects
Martimathin-MA, et al.
Coatings, 9(8), 474-474 (2020)
Assay to Measure Interactions between Purified Drp1 and Synthetic Liposomes
Adachi Y, et al.
Bio-protocol, 7(9) (2017)
Chelsea A Kraynak et al.
Acta biomaterialia, 108, 250-260 (2020-04-07)
Macrophages play a critical role in the initiation, maintenance, and resolution of inflammation because of their diverse and plastic phenotypic responses to extracellular stimuli. Inflammatory stimuli drive the recruitment and activation of inflammatory (M1) macrophages, capable of significant cytokine production
Koshiki Mino et al.
FEBS letters, 551(1-3), 133-138 (2003-09-11)
O-Acetylserine sulfhydrylase (OASS), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes the synthesis of L-cysteine from O-acetyl-L-serine and sulfide. O-Acetyl-L-serine is labile at high temperatures at which hyperthermophilic archaea live. Herein, a study of the substrate specificity of OASS from Aeropyrum pernix
Ana Cristina Racca et al.
Frontiers in oncology, 9, 544-544 (2019-07-06)
Tumor cells require high rates of lipid synthesis to support membrane biogenesis for their exacerbated growth. The only two proteins known that activate phospholipid synthesis are Fra-1 and c-Fos, two members of the AP-1 family of transcription factors. These proteins
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