Product Name
Monolyso Heart CA, Avanti Research™ - A Croda Brand 850081P, powder
InChI key
BYCQHLJVUPZGJA-LWABKDCLSA-L
SMILES string
O=P([O-])(OC[C@]([H])(O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (850081P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850081P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
General description
Monolysocardiolipin (MLCL) is a class of phospholipid related to cardiolipin. MLCL is a triacylated phospholipid, uncommon in bacterial or eukaryotic membranes. MLCL is prepared from cardiolipin by the hydrolysis action of phospholipase A2 (PLA2).
Application
Monolyso Heart CA is suitable for use:
- as substrate for the synthesis of cardiolipin by the enzyme acyl-CoA:lysocardiolipin acyltransferase (ACLAT1)
- as substrate for the assay of mitochondrial monolysocardiolipin acyltransferase (MLCL AT) activity
- in the preparation of affinity resin MLCL-adriamycin-agarose for the purification of MLCL AT
Biochem/physiol Actions
Monolysocardiolipin (MLCL) is a substrate for the biosynthesis of cardiolipin in heart by the activity of MLCL acyltransferase. MLCL is a marker for Barth syndrome. MLCL is implicated in apoptosis.
Packaging
5 mL Clear Glass Sealed Ampule (850081P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Monolysocardiolipin: improved preparation with high yield
Kim J and Hoppel CL
Journal of Lipid Research, 52(2), 389-392 (2011)
Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii
Lopalco P, et al.
Scientific Reports, 7(1), 2972-2972 (2017)
Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome
Van Werkhoven MA, et al.
Journal of Lipid Research, 47(10), 2346-2351 (2006)
Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
Taylor WA and Hatch GM
The Journal of Biological Chemistry, 284(44), 30360-30371 (2009)
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart
Mutter T, et al.
The Biochemical Journal, 346(2), 403-406 (2000)
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