产品名称
单溶血型心磷脂, Avanti Research™ - A Croda Brand 850081P, powder
InChI key
BYCQHLJVUPZGJA-LWABKDCLSA-L
SMILES string
O=P([O-])(OC[C@]([H])(O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (850081P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850081P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
General description
单溶心磷脂（MLCL）是一类与心磷脂有关的磷脂。 MLCL是一种三酰化磷脂，在细菌或真核细胞膜中并不常见。 MLCL是心磷脂经过磷脂酶A2（PLA2）的水解而获得的。
Application
Monolyso Heart CA适用于：
- 作为酰基辅酶A:心磷脂酰基转移酶（ACLAT1）合成心磷脂的底物
- 作为线粒体单溶血心磷脂酰基转移酶（MLCL AT）活性测定的底物
- 制备用于纯化MLCL AT的亲和树脂MLCL-阿霉素-琼脂糖
Biochem/physiol Actions
单溶心磷脂（MLCL）是心脏利用MLCL酰基转移酶活性进行心磷脂生物合成的底物。 MLCL是Barth综合征的标志物。 MLCL与细胞凋亡有关。
Packaging
5 mL透明玻璃密封安瓿（850081P-10mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Monolysocardiolipin: improved preparation with high yield
Kim J and Hoppel CL
Journal of Lipid Research, 52(2), 389-392 (2011)
Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii
Lopalco P, et al.
Scientific Reports, 7(1), 2972-2972 (2017)
Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome
Van Werkhoven MA, et al.
Journal of Lipid Research, 47(10), 2346-2351 (2006)
Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
Taylor WA and Hatch GM
The Journal of Biological Chemistry, 284(44), 30360-30371 (2009)
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart
Mutter T, et al.
The Biochemical Journal, 346(2), 403-406 (2000)
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