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Merck
CN

850091P

Avanti

Liver Lyso PI

Avanti Research™ - A Croda Brand

Synonym(s):

L-α-lysophosphatidylinositol (Liver, Bovine) (sodium salt)

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About This Item

CAS Number:
796963-93-4
MDL number:
MFCD28143631
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

Liver Lyso PI, Avanti Research™ - A Croda Brand 850091P, powder

InChI

1S/C27H53O12P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(29)37-18-20(28)19-38-40(35,36)39-27-25(33)23(31)22(30)24(32)26(27)34;/h20,22-28,30-34H,2-19H2,1H3,(H,35,36);/q;+1/p-1/t20-,22-,23-,24+,25-,26-,27-;/m1./s1

InChI key

AHPIBXQPCBITBP-FJYNCLFYSA-M

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

assay

>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)

form

powder

packaging

pkg of 1 × 10 mg (850091P-10mg)
pkg of 1 × 5 mg (850091P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850091P

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Application

Liver Lyso PI has been used to enhance the binding efficiency of ovalbumin peptide to class II major histocompatibility molecules.

Biochem/physiol Actions

Lysophosphotidylinositol (LPI) is involved in metabolism and glucose homeostasis. It also affects cellular growth, differentiation and motility of various cells, such as nerve cells, endothelial cells and cancer cells. LPI is an endogenous ligand for G-protein coupled receptor, GPR55.

General description

Lysophosphotidylinositol (LPI) is a bioactive lipid obtained from the phospholipase A (PLA) family of lipases.

Packaging

5 mL Amber Glass Screw Cap Vial (850091P-10mg)
5 mL Amber Glass Screw Cap Vial (850091P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Lysophosphatidylinositol signalling and metabolic diseases
Arifin S A and Falasca M
Metabolites, 6(1), 6-6 (2016)
The lysophosphatidylinositol receptor GPR55 modulates pain perception in the periaqueductal gray
Deliu E, et al.
Molecular Pharmacology, 88(2), 265-272 (2015)
Phospholipids enhance the binding of peptides to class II major histocompatibility molecules
Roof R W, et al.
Proceedings of the National Academy of Sciences of the USA, 87(5), 1735-1739 (1990)
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells

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