产品名称
Liver Lyso PI, Avanti Research™ - A Croda Brand 850091P, powder
InChI
1S/C27H53O12P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(29)37-18-20(28)19-38-40(35,36)39-27-25(33)23(31)22(30)24(32)26(27)34;/h20,22-28,30-34H,2-19H2,1H3,(H,35,36);/q;+1/p-1/t20-,22-,23-,24+,25-,26-,27-;/m1./s1
InChI key
AHPIBXQPCBITBP-FJYNCLFYSA-M
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
assay
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
form
powder
packaging
pkg of 1 × 10 mg (850091P-10mg)
pkg of 1 × 5 mg (850091P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850091P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
Application
Liver Lyso PI has been used to enhance the binding efficiency of ovalbumin peptide to class II major histocompatibility molecules.
Biochem/physiol Actions
Lysophosphotidylinositol (LPI) is involved in metabolism and glucose homeostasis. It also affects cellular growth, differentiation and motility of various cells, such as nerve cells, endothelial cells and cancer cells. LPI is an endogenous ligand for G-protein coupled receptor, GPR55.
General description
Lysophosphotidylinositol (LPI) is a bioactive lipid obtained from the phospholipase A (PLA) family of lipases.
Packaging
5 mL Amber Glass Screw Cap Vial (850091P-10mg)
5 mL Amber Glass Screw Cap Vial (850091P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Lysophosphatidylinositol signalling and metabolic diseases
Arifin S A and Falasca M
Metabolites, 6(1), 6-6 (2016)
The lysophosphatidylinositol receptor GPR55 modulates pain perception in the periaqueductal gray
Deliu E, et al.
Molecular Pharmacology, 88(2), 265-272 (2015)
Phospholipids enhance the binding of peptides to class II major histocompatibility molecules
Roof R W, et al.
Proceedings of the National Academy of Sciences of the USA, 87(5), 1735-1739 (1990)
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
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