All Photos(2)

Documents

850365P

Avanti

18:0 PC (DSPC)

Name: 18:0 PC (DSPC)
Brand: AVANTI

Avanti Polar Lipids

Sign Into View Organizational & Contract Pricing

All Photos(2)

Synonym(s):

1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)

Empirical Formula (Hill Notation):

C₄₄H₈₈NO₈P

CAS Number:

816-94-4

Molecular Weight:

790.15

NACRES:

NA.25

description

1,2-distearoyl-sn-glycero-3-phosphocholine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850365P-1G)
pkg of 1 × 200 mg (850365P-200MG)
pkg of 1 × 25 mg (850365P-25MG)
pkg of 1 × 500 mg (850365P-500MG)

manufacturer/tradename

Avanti Polar Lipids

application(s)

advanced drug delivery

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:

in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
in the preparation of liposomes for immobilization studies
in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)

20 mL Clear Glass Screw Cap Vial (850365P-500MG)

5 mL Amber Glass Screw Cap Vial (850365P-200MG)

5 mL Amber Glass Screw Cap Vial (850365P-25MG)

also commonly purchased with this product

Product No.

Description

Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

How to Find the Product Number

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503

Product Number

-

25G

Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

How to Find a Lot/Batch Number for COA

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').
For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').
For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Comparative study of PEGylated and conventional liposomes as carriers for shikonin

Tsermentseli S, et al.

Fluids, 3(2), 36-36 (2018)

Investigating the structure of multicomponent gel-phase lipid bilayers

Hartkamp R, et al.

Biophysical Journal, 111(4), 813-823 (2016)

Biomolecule delivery into canola protoplasts by centrifuging cells with microbubbles

He C, et al.

Febs Letters, 587(3), 285-290 (2013)

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.

Kenneth L Clark et al.

Molecular therapy. Nucleic acids, 2, e65-e65 (2013-01-17)

Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC). To identify a small-interfering RNA (siRNA) which selectively inhibits ENaC expression

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.

Viktoriya Dubrovskaya et al.

Immunity, 51(5), 915-929 (2019-11-17)

The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein determinants are occluded by self-N-glycan shielding, limiting B cell recognition of the underlying polypeptide surface. The exceptions to

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Documents

18:0 PC (DSPC)

Avanti Polar Lipids

Properties

description

Assay

form

packaging

manufacturer/tradename

application(s)

lipid type

shipped in

storage temp.

SMILES string

InChI

InChI key

Description

General description

Application

Biochem/physiol Actions

Packaging

Related Products

also commonly purchased with this product

Safety Information

Storage Class Code

WGK

Flash Point(F)

Flash Point(C)

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Difficulty Finding Your Product Or Lot/Batch Number?

Aldrich Products

Not Finding What You Are Looking For?

Peer Reviewed Papers

Technical Service