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Merck
CN

850582P

Avanti

Laurdan

Avanti Research™ - A Croda Brand

Synonym(s):

1-(6-(dimethylamino)naphthalen-2-yl)dodecan-1-one, 6-dodecanoyl-2-dimethylaminonaphthalene

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About This Item

Empirical Formula (Hill Notation):
C24H35NO
CAS Number:
74515-25-6
Molecular Weight:
353.54
MDL number:
MFCD00467560
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Assay

99% (TLC)

form

powder

packaging

package of 1 × 100 μg
package of 1 × 500 μg

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

N(C)(C)c1cc2c(cc(cc2)C(=O)CCCCCCCCCCC)cc1

InChI key

JHDGGIDITFLRJY-UHFFFAOYSA-N

General description

1-(6-(dimethylamino)naphthalen-2-yl) dodecan-1-one or Laurdan is a derivative of naphthalene and is a fluorescent membrane probe. It is present at the hydrophilic-hydrophobic interface of the lipid bilayer, wherein the lauric acid tail is attached attached in the phospholipid acyl chain area.

Biochem/physiol Actions

1-(6-(dimethylamino)naphthalen-2-yl) dodecan-1-one or Laurdan exhibits spectral sensitivity to phospholipid phase state. It also exhibits fluorescence property. Laurdan is implicated in bilayer property studies of natural and artificial membranes due to its sensitivity to solvent relaxation effect.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850582p-100UG) 2 mL Amber Serum Vial with Stopper and Crimp Cap (850582p-500UG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Laurdan and Prodan as polarity-sensitive fluorescent membrane probes
Parasassi T, et al.
Journal of Fluorescence, 8(4), 365-373 (1998)
Two-photon fluorescence microscopy of laurdan generalized polarization domains in model and natural membranes
Parasassi T, et al.
Biophysical Journal, 72(6), 2413-2429 (1997)
Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order
Harris F M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1565(1), 123-128 (2002)
Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence.
Parasassi T, et al.
Biophysical Journal, 60(1), 179-179 (1991)

Articles

Fluorescent Lipid Probes - Avanti Research™

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