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850715P

Avanti

18:0 PE

Avanti Polar Lipids

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Synonym(s):
1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine; DSPE; PE(18:0/18:0); 110634
Empirical Formula (Hill Notation):
C41H82NO8P
CAS Number:
1069-79-0
Molecular Weight:
748.07

description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850715P-1g)
pkg of 1 × 200 mg (850715P-200mg)
pkg of 1 × 25 mg (850715P-25mg)
pkg of 1 × 500 mg (850715P-500mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

InChI

1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)

InChI key

LVNGJLRDBYCPGB-UHFFFAOYSA-N

General description

Phosphatidylethanolamine is an aminophospholipid, which is found in eukaryotic and prokaryotic cells. It is one of the most abundant glycerophospholipids in biological membranes. Phosphatidylethanolamine is found in nervous tissue.

Application

18:0 PE has been used to prepare the intermediate 1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine (DSPE)-polyethylene glycol (PEG)-SPDP for the preparation of Lipid-PEG-CpG.

Biochem/physiol Actions

Phosphatidylethanolamine forms pure lipid structures. It modulates membrane fluidity in eukaryotic cells. Phosphatidylethanolamine plays an important role in autophagy, cell division and protein folding. It acts as a precursor for the synthesis of various protein modifications. Phosphatidylethanolamine functions as an intermediate for the synthesis of glycerophospholipid classes.

Packaging

20 mL Clear Glass Screw Cap Vial (850715P-1g)
20 mL Clear Glass Screw Cap Vial (850715P-500mg)
5 mL Amber Glass Screw Cap Vial (850715P-200mg)
5 mL Amber Glass Screw Cap Vial (850715P-25mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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The Membranes of Cells (2016)
Metronomic doses of temozolomide enhance the efficacy of carbon nanotube CpG immunotherapy in an invasive glioma model
Ouyang M, et al.
Testing, 11(2), e0148139-e0148139 (2016)
An Introduction to Biological Membranes: Composition, Structure and Function (2016)
Suraj Baskararaj et al.
3 Biotech, 10(3), 136-136 (2020-03-12)
This study aimed to formulate and characterize the folate receptor-targeted PEGylated liposome encapsulating bioactive compounds from Kappaphycus alvarezii to enhance the anticancer activity. Twenty valued bioactive compounds (3-hydroxy benzoicacid, gallicacid, chlorogenicacid, cinnamicacid, artemiseole, hydrazine carbothioamide, etc.,) are confirmed from methanol
Lei Wu et al.
Journal of controlled release : official journal of the Controlled Release Society, 323, 151-160 (2020-04-12)
The epithelium is a formidable barrier to the absorption of orally delivered nano-vehicles. Here, by exploring a nutrient-absorption pathway, a self-amplified nanoplatform was developed to promote apical-to-basolateral transcytosis across the epithelium. The nanoplatform consisted of fructose-modified polyethylene glycol coated nanoparticles
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