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857341P

Avanti

VPC 12249 (S)

Name: VPC 12249 (S)
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

[(2S)-2-[[(Z)-octadec-9-enoyl]amino]-3-(4-phenylmethoxyphenyl)propyl] hydrogen phosphate

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₅₅N₂O₆P

CAS Number:

799268-73-8

Molecular Weight:

618.78

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

VPC 12249 (S), (S)-phosphoric acid mono-[3-(4-benzyloxy-phenyl)-2-octadec-9-enoylamino-propyl] ester (ammonium salt), powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857341P-1mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 857341P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](COP(O)([O-])=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1.[NH4+]

Description

General description

VPC 12249 is an N-acyl (oleoyl) serine phosphate-based compound.

Application

VPC 12249 has been used as lysophosphatidic acid (LPA)_1/3receptor antagonist in various experimental studies.

Biochem/physiol Actions

Lysophosphatidic acids (LPAs) are bioactive lipid mediators. It interacts with at least six specific LPA receptors (LPA1-6) to mediate extracellular signaling pathway. LPA and its receptors (LPA_1-3) are implicated in the pathogenesis of radiation pneumonitis (RP). VPC 12249 (S) inhibits the binding ofLPA to LPA₁ and LPA₃ receptor.

Packaging

5 mL Amber Glass Screw Cap Vial (857341P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

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