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857341P

Avanti

VPC 12249 (S)

Avanti Research™ - A Croda Brand

Synonym(s):

[(2S)-2-[[(Z)-octadec-9-enoyl]amino]-3-(4-phenylmethoxyphenyl)propyl] hydrogen phosphate

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About This Item

Empirical Formula (Hill Notation):
C34H55N2O6P
CAS Number:
799268-73-8
Molecular Weight:
618.78
UNSPSC Code:
12352211
NACRES:
NA.25

Product Name

VPC 12249 (S), (S)-phosphoric acid mono-[3-(4-benzyloxy-phenyl)-2-octadec-9-enoylamino-propyl] ester (ammonium salt), powder

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857341P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857341P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](COP(O)([O-])=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1.[NH4+]

General description

VPC 12249 is an N-acyl (oleoyl) serine phosphate-based compound.

Application

VPC 12249 has been used as lysophosphatidic acid (LPA)1/3 receptor antagonist in various experimental studies.

Biochem/physiol Actions

Lysophosphatidic acids (LPAs) are bioactive lipid mediators. It interacts with at least six specific LPA receptors (LPA1-6) to mediate extracellular signaling pathway. LPA and its receptors (LPA1-3) are implicated in the pathogenesis of radiation pneumonitis (RP). VPC 12249 (S) inhibits the binding ofLPA to LPA1 and LPA3 receptor.

Packaging

5 mL Amber Glass Screw Cap Vial (857341P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

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