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关于此项目
经验公式（希尔记法）:
C18H28F3N2O6P
化学文摘社编号:
分子量:
456.39
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
W146, (R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857390P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857390P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
Application
W146 has been used:
- to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
- to study oxidative stress and drug treatment in granulosa cells
- to evaluate its effects on transendothelial electrical resistance (TEER)
Biochem/physiol Actions
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
Packaging
5 mL Amber Glass Screw Cap Vial (857390P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available