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关于此项目
经验公式（希尔记法）:
C18H28F3N2O6P
化学文摘社编号:
分子量:
456.39
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
W146, (R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857390P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857390P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
Application
W146 has been used:
- to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
- to study oxidative stress and drug treatment in granulosa cells
- to evaluate its effects on transendothelial electrical resistance (TEER)
Biochem/physiol Actions
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
Packaging
5 mL Amber Glass Screw Cap Vial (857390P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
S1P, dihydro-S1P and C24: 1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves KM, et al.
Lipids in Health and Disease, 10(1), 70-70 (2011)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway
Nakahara T, et al.
Fertility and Sterility, 98(4) (2012)
M Germana Sanna et al.
Nature chemical biology, 2(8), 434-441 (2006-07-11)
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through
Kelley M Argraves et al.
The Journal of biological chemistry, 283(36), 25074-25081 (2008-07-09)
High density lipoproteins (HDL) are major plasma carriers of sphingosine 1-phosphate (S1P). Here we show that HDL increases endothelial barrier integrity as measured by electric cell substrate impedance sensing. S1P was implicated as the mediator in this process through findings
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