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About This Item
Empirical Formula (Hill Notation):
C27H43N3O4
CAS Number:
Molecular Weight:
473.65
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
IG7, Avanti Research™ - A Croda Brand, powder
InChI key
RAXJRRQLMVPSON-NLFFAJNJSA-N
SMILES string
C[C@@H](O)[C@H](NC(C(N1)=CC2=C1C=CC(OC)=C2)=O)C(NCCCCCCCCCCCCC)=O
assay
99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857410P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
IG7 is a ceramide analog.
Biochem/physiol Actions
IG7 is potent in enhancing Fas ligand (FasL) induced apoptosis in colon carcinoma cells SW480 and RKO. IG7 enhances FasL mediated phosphorylation of p38 and janus kinase (JNK). IG7 enhances nuclear factor-kappa B (NF-κB) activation by FasL. IG7 exhibits low toxicity.
Packaging
5ML Glass Amber Screw Cap Vial (857410P-1MG)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes
Coe GL, et al.
Scientific Reports, 6, 30816-30816 (2016)
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