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Merck
CN

857410P

Avanti

IG7

Avanti Research™ - A Croda Brand

别名:

N-((2S,3R)-3-hydroxy-1-oxo-1-(tridecylamino)butan-2-yl)-5-methoxy-1H-indole-2-carboxamide

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关于此项目

经验公式（希尔记法）:
C27H43N3O4
化学文摘社编号:
2132345-13-0
分子量:
473.65
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

IG7, Avanti Research™ - A Croda Brand, powder

InChI key

RAXJRRQLMVPSON-NLFFAJNJSA-N

SMILES string

C[C@@H](O)[C@H](NC(C(N1)=CC2=C1C=CC(OC)=C2)=O)C(NCCCCCCCCCCCCC)=O

assay

99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857410P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

bioactive lipids

shipped in

dry ice

storage temp.

−20°C

General description

IG7 is a ceramide analog.

Biochem/physiol Actions

IG7 is potent in enhancing Fas ligand (FasL) induced apoptosis in colon carcinoma cells SW480 and RKO. IG7 enhances FasL mediated phosphorylation of p38 and janus kinase (JNK). IG7 enhances nuclear factor-kappa B (NF-κB) activation by FasL. IG7 exhibits low toxicity.

Packaging

5ML Glass Amber Screw Cap Vial (857410P-1MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes
Coe GL, et al.
Scientific Reports, 6, 30816-30816 (2016)

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