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About This Item
Empirical Formula (Hill Notation):
C16H25OD5
CAS Number:
Molecular Weight:
243.44
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
Product Name
16:1 aldehyde-d5, (2E)-hexadecenal(d5), powder
InChI
1S/C16H30O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h14-16H,2-13H2,1H3/b15-14+/i1D3,2D2
InChI key
KLJFYXOVGVXZKT-AKCNZVNDSA-N
SMILES string
[2H]C([2H])([2H])C([2H])([2H])CCCCCCCCCCC/C=C/C([H])=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857461P-1mg), pkg of 1 × 5 mg (857461P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857461P
lipid type
sphingolipids
deuterated lipids
shipped in
dry ice
storage temp.
−20°C
General description
Fatty aldehydes are enzymatically converted to fatty alcohols and fatty acids. When assessing S1P lyase enzymatic activity, the estimation of fatty aldehyde stability during the reaction is required. The (2E)-hexadecenal(d5) (857461) is suitable as the internal standard for LC/MS/MS approaches to quantify the product of S1P degradation by S1P lyase, (2E)-hexadecenal; however, a natural (2E)-hexadecenal (857469) is needed to evaluate its stability during enzymatic reaction. The method describing the details of the use of both (2E)-hexadecenal(d5) and (2E)-hexadecenal for LC/MS/MS-based characterization of S1P lyase reaction is in preparation for publication by Berdyshev et al.Personal communication from Evgeny Berdyshev, Ph.D., Assistant Professor, University of Illinois at Chicago.
Application
16:1 aldehyde-d5 has been used as an internal standard in lipid extraction from lung tissue and liquid chromatography/with tandem mass spectrometry analysis (LC/MS/MS). It has also been used as a standard in lipid extraction from plasma, derivatization of 2E-hexadecenal for quantification in quadrupole/time-of-flight (QTOF) mass spectrometer connected with a rapid-resolution-liquid-chromatography (RRLC).
Biochem/physiol Actions
16:1 aldehyde is a predominant fatty aldehyde in phospholipid of bovine adipose tissue, Lactobacillus and few bacteria like Selenomonas ruminantium, when grown on glucose and even-numbered volatile fatty acids. It is one of the main aldehydes in plasmalogen of notched brittle star, Ophiura sarsi.
Packaging
5 mL Amber Glass Screw Cap Vial (857461P-1mg)
5 mL Amber Glass Screw Cap Vial (857461P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement
Luth A, et al.
Analytica Chimica Acta, 722(8), 70-79 (2012)
Marine Biogenic Lipids, Fats & Oils, 213-213 (1989)
Cellular fatty acid and fatty aldehyde composition of rumen bacteria
Miyagawa E
The Journal of General and Applied Microbiology, 28(5), 389-408 (1982)
Lipid Metabolism in Ruminant Animals (2014)
Irina Gorshkova et al.
Journal of lipid research, 53(8), 1553-1568 (2012-05-23)
The enforcement of sphingosine-1-phosphate (S1P) signaling network protects from radiation-induced pneumonitis. We now demonstrate that, in contrast to early postirradiation period, late postirradiation sphingosine kinase-1 (SphK1) and sphingoid base-1-phosphates are associated with radiation-induced pulmonary fibrosis (RIF). Using the mouse model
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