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Merck
CN

857504P

Avanti

16:0-i15:0 PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-Palmitoyl-(13-methylmyristoyl)-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C39H78NO8P
CAS Number:
1830316-07-8
Molecular Weight:
720.01
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

16:0-i15:0 PC, Avanti Research™ - A Croda Brand (857504P), powder

InChI

1S/C39H78NO8P/c1-7-8-9-10-11-12-13-14-15-18-21-24-27-30-38(41)45-34-37(35-47-49(43,44)46-33-32-40(4,5)6)48-39(42)31-28-25-22-19-16-17-20-23-26-29-36(2)3/h36-37H,7-35H2,1-6H3/t37-/m1/s1

InChI key

GKOJJQSSOMSCPH-DIPNUNPCSA-N

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCC(C)C)=O)COC(CCCCCCCCCCCCCCC)=O)=O

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (857504P-10MG), pkg of 1 × 5 mg (857504P-5MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand (857504P)

lipid type

phospholipids
bacterial lipids

shipped in

dry ice

storage temp.

−20°C

General description

16:0-i15:0 phosphatidylcholine (PC) is an asymmetric saturated PC. Phosphatidylcholine (PC) is one of the major zwitterionic glycerophospholipids of the eukaryotic membranes. PC is synthesized in higher eukaryotes via two pathways namely the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway. PC is a cylindrical shaped molecule.

Biochem/physiol Actions

16:0-i15:0 is used in the preparation of liposomes and large unilamellar vesicles. Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. Biosynthesis of PC is essential for normal very low density lipoprotein secretion from hepatocytes. PC is the dominant phospholipid present in cancer and non-neoplastic tissues.

Packaging

5 mL Amber Glass Screw Cap Vial (857504P-5MG and 857504P-10MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Branched phospholipids render lipid vesicles more susceptible to membrane-active peptides
Mitchell NJ, et al.
Biochimica et biophysica acta. General subjects, 1858(5), 988-994 (2016)
Thematic review series: glycerolipids. Phosphatidylcholine and choline homeostasis
Li Z and Vance DE
Journal of Lipid Research, 49(6), 1187-1194 (2008)
Nobuya Kurabe et al.
Cancer science, 104(10), 1295-1302 (2013-07-03)
The identification of cancer biomarkers is critical for target-linked cancer therapy. The overall level of phosphatidylcholine (PC) is elevated in colorectal cancer (CRC). To investigate which species of PC is overexpressed in colorectal cancer, an imaging mass spectrometry was performed
The Kennedy pathway?de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
Gibellini F and Smith TK
IUBMB Life, 62(6), 414-428 (2010)

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