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Merck
CN

858125C

Avanti

18:1 Lyso PG

Avanti Research™ - A Croda Brand

Synonym(s):

1-oleoy-sn-glycero-3-phospho-(1′racglycerol) (sodium salt); PG(18:1(9Z)/0:0); 110714

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About This Item

Empirical Formula (Hill Notation):
C24H46O9PNa
CAS Number:
326495-24-3
Molecular Weight:
532.58
MDL number:
MFCD00672604
NACRES:
NA.25
UNSPSC Code:
51191904

Key Documents

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Product Name

18:1 Lyso PG, 1-oleoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt), chloroform

assay

>99% (LPG; may contain up to 10% of the 2-LPG isomer, TLC)

form

liquid

packaging

pkg of 5 × 4 mL (858125C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 858125C

concentration

25 mg/mL (858125C-500mg)

shipped in

dry ice

storage temp.

−20°C

Application

18:1 Lyso PG has been used as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions.

Biochem/physiol Actions

Lyso phosphoglycerol (Lyso PG) and acyl-CoA acts as a substrate for lysophosphatidylglycerol acyltransferase 1 (LPGAT1) to synthesize phosphoglycerol. Lyso-phospholipids are nonbilayer-forming lipids. Accumulation of lysophospholipids in bacterial membranes disrupt the membrane integrity due to its detergent- like physical property.

General description

18:1 Lyso phosphoglycerol is a lyso-phospholipid detergent. Lyso-phospholipids are produced in γ-proteobacteria by lipoprotein acyltransferase activity. These lipids are found in minimal amount in normal bacterial membranes.

Packaging

5 mL Clear Glass Sealed Ampule (858125C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

危险化学品
易制毒化学品（2类）
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Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis
Chadwick A, et al.
Protein Expression and Purification, 107, 35-42 (2015)
Hideo Shindou et al.
The Journal of biological chemistry, 284(1), 1-5 (2008-08-23)
Cell membranes contain several classes of glycerophospholipids, which have numerous structural and functional roles in the cells. Polyunsaturated fatty acids, including arachidonic acid and eicosapentaenoic acid, are located at the sn-2 (but not sn-1)-position of glycerophospholipids in an asymmetrical manner.
Comprehensive untargeted lipidomic analysis using core-shell C30 particle column and high field orbitrap mass spectrometer
Narvaez-Rivas M and Zhang Q
Journal of Chromatography A, 1440, 123-134 (2016)
Substrate selectivity of lysophospholipid transporter LplT involved in membrane phospholipid remodeling in Escherichia coli
Lin Y, et al.
The Journal of Biological Chemistry, 291(5), 2136-2149 (2016)
Mónica Narváez-Rivas et al.
Journal of chromatography. A, 1440, 123-134 (2016-03-02)
The goal of untargeted lipidomics is to have high throughput, yet comprehensive and unambiguous identification and quantification of lipids. Novel stationary phases in LC separation and new mass spectrometric instruments capable of high mass resolving power and faster scanning rate

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