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经验公式（希尔记法）:
C22H43NO3
化学文摘社编号:
分子量:
369.58
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C4 Ceramide (d18:1/4:0), Avanti Research™ - A Croda Brand 860504P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860504P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860504P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C22H43NO3/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-18-21(25)20(19-24)23-22(26)17-4-2/h16,18,20-21,24-25H,3-15,17,19H2,1-2H3,(H,23,26)/b18-16+/t20-,21+/m0/s1
InChI key
UCBLGIBMIAFISC-CQLAPORSSA-N
General description
C4 Ceramide (d18:1/4:0) or N-butyroyl-D-erythro-sphingosine is a synthetic ceramide containing sphingosine with butyric acid. It is a non-toxic, short-chain sphingolipid.
Application
C4 Ceramide (d18:1/4:0) has been used to study its role in rescuing and stabilizing ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).
Biochem/physiol Actions
C4 Ceramide (d18:1/4:0) is implicated in a series of mutual autophosphorylation and phosphorylation actions between 3-phosphoinositide-dependent kinase 1 (PDK1) and serum/glucocorticoid-induced protein kinase 1 (SGK1). It stimulates cyclic adenosine monophosphate (cAMP)-activated chloride secretion and represses hypersecretion of interleukin-8 (IL-8). C4 Ceramide might be a potential therapeutic for cystic fibrosis (CF).
Packaging
5 mL Amber Glass Screw Cap Vial (860504P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable